Nouvel étalon interne qNMR pour les produits pharmaceutiques et d’autres composés organofluorés
Organofluorine compounds represent an important class of pharmaceuticals, about 20% of which are fluorinated compounds. Other application areas for organofluorides are agriculture, cosmetics, biomolecule analysis and functionalized materials. Their production requires rigorous manufacturing processes and purity characterization. Accurate purity assignment can be performed using Fluorine-19 quantitative nuclear magnetic resonance (19F qNMR) with appropriate internal standards and experimental methods.
The internal standard reference document was published by the BIPM in collaboration with seconded experts from INMETRO (Brazil), BAM (Germany), INTI (Argentina) and NMIJ (Japan). The project was established to enable the application of fluorine based qNMR methods for rapid, SI-traceable purity assignment, and provide an alternative to the application of proton based methods where overlapping signals can limit the application of the technique.