Comparison Display

CIPM MRA PARTICIPANTS

The KCDB - the BIPM key comparison database – supports the CIPM MRA. The KCDB contains information on the internationally recognized Calibration and Measurement Capabilities (CMCs) for services available from the participating institutes, and the key and supplementary comparisons supporting these CMCs.

All data listed in the KCDB have been reviewed and approved within the CIPM Mutual Recognition Arrangement

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CIPM MRA PARTICIPANTS

CMC statistics

Published CMC statistics

Comparison statistics

MEASURAND : Mass fraction of Estradiol in the CCQM-K55.a samples

Degrees of equivalence : offset D_i and expanded uncertainty (k = 2) U_i expressed in mg/g, and also in relative terms

x_R = 984.3 mg/g
2 u_R= 0.8 mg/g

MEASURAND : Mass fraction of Related Structure Impurities in the CCQM-K55.a samples

Degrees of equivalence : offset D_i and expanded uncertainty (k = 2) U_i expressed in mg/g, and also in relative terms

x_R = 8.65 mg/g
2 u_R= 0.32 mg/g

MEASURAND : Mass fraction of Water in the CCQM-K55.a samples

Degrees of equivalence : offset D_i and expanded uncertainty (k = 2) U_i expressed in mg/g, and also in relative terms

x_R = 6.75 mg/g
2 u_R= 0.42 mg/g

MEASURAND : Mass fraction of Volatile Organics in the CCQM-K55.a samples

Degrees of equivalence : offset D_i and expanded uncertainty (k = 2) U_i expressed in mg/g, and also in relative terms

x_R = 0.10 mg/g
2 u_R= 0.12 mg/g

MEASURAND : Mass fraction of Non-Volatile Content in the CCQM-K55.a samples

Degrees of equivalence : offset D_i and expanded uncertainty (k = 2) U_i expressed in mg/g, and also in relative terms

x_R = 0.20 mg/g
2 u_R= 0.24 mg/g

MEASURAND : Mass fraction of Estradiol in the CCQM-K55.a samples

Degrees of equivalence : offset D_i and expanded uncertainty (k = 2) U_i expressed in mg/g
x_R = 984.3 mg/g and 2 u_R= 0.8 mg/g

Results are presented under A4 printable format in Summary Results (PDF file).

MEASURAND : Mass fraction of Related Structure Impurities in the CCQM-K55.a samples

Degrees of equivalence : offset D_i and expanded uncertainty (k = 2) U_i expressed in mg/g
x_R = 8.65 mg/g and 2 u_R= 0.32 mg/g

Results are presented under A4 printable format in Summary Results (PDF file).

MEASURAND : Mass fraction of Water in the CCQM-K55.a samples

Degrees of equivalence : offset D_i and expanded uncertainty (k = 2) U_i expressed in mg/g
x_R = 6.75 mg/g and 2 u_R= 0.42 mg/g

Results are presented under A4 printable format in Summary Results (PDF file).

MEASURAND : Mass fraction of Volatile Organics in the CCQM-K55.a samples

Degrees of equivalence : offset D_i and expanded uncertainty (k = 2) U_i expressed in mg/g
x_R = 0.10 mg/g and 2 u_R= 0.12 mg/g

Results are presented under A4 printable format in Summary Results (PDF file).

MEASURAND : Mass fraction of Non-Volatile Content in the CCQM-K55.a samples

Degrees of equivalence : offset D_i and expanded uncertainty (k = 2) U_i expressed in mg/g
x_R = 0.20 mg/g and 2 u_R= 0.24 mg/g

Results are presented under A4 printable format in Summary Results (PDF file).

Comparison

Comparison close

CCQM-K55.a

Information & contact
Participants

Metrology area, Sub-field	Chemistry and Biology, Organics
Description	Purity assessment of high purity organic materials: 17beta-Estradiol
Time of measurements	2008 - 2009
Status	Approved for equivalence

Final Reports of the comparisons	CCQM-K55.a Final Report, 2012, 33 pages Metrologia, 2012, 49, Tech. Suppl., 08009
Measurand	Mass fraction of 17beta-Estradiol Nominal value > 970 mg/g
Transfer device	Dedicated samples

Comparison type	Key Comparison
Consultative Committee	CCQM (Consultative Committee for Amount of Substance)
Conducted by	CCQM (Consultative Committee for Amount of Substance)
Comments	Results published on 22 August 2012 Purity assessment of high purity organic materials: 17beta-Estradiol
Pilot institute	BIPM Bureau International des Poids et Mesures BIPM - International Organization
Contact person	Steven Westwood +33 (0) 1 45 07 70 57

Pilot laboratory
BIPM	Bureau International des Poids et Mesures, BIPM - International Organization, N/A

BAM	Bundesanstalt für Materialforschung und -prüfung, Germany, EURAMET

CENAM

Centro Nacional de Metrologia, Mexico, SIM

GL	Government Laboratory, Hong Kong, China, APMP

INMETRO

Instituto Nacional de Metrologia, Qualidade e Tecnologia, Brazil, SIM

LGC	Laboratory of the Government Chemist, United Kingdom, EURAMET

NIM	National Institute of Metrology, China, APMP

NIST	National Institute of Standards and Technology, United States, SIM

NMIA	National Measurement Institute, Australia, Australia, APMP

NMIJ AIST

National Metrology Institute of Japan, Japan, APMP

NMISA

National Metrology Institute of South Africa, South Africa, AFRIMETS

NRC	National Research Council, Canada, SIM

MEASURAND : Mass fraction of Estradiol in the CCQM-K55.a samples

The key comparison reference value for the mass fraction of estradiol, x_R, was calculated by subtraction from the limit value of 1000 mg/g of the summation of the individual estimates for each contributing class of impurities present in CCQM-K55.a samples, as explained in page 21 of the Final Report.
Its standard uncertainty, u_R, is computed by combination in quadrature of the uncertainties associated with each contributing impurity estimate and also uncertainties in the inter-unit homogeneity of water and related structure impurity content.
x_R = 984.3 mg/g, u_R = 0.41 mg/g

The degree of equivalence of laboratory i with respect to the key comparison reference value is given by a pair of terms: D_i = (x_i - x_R) and U_i, its expanded uncertainty (k = 2), both expressed in mg/g, with U_i = 2(u_i² + u_R²)^1/2.

No pair-wise degrees of equivalence are computed for this comparison.

MEASURAND : Mass fraction of Related Structure Impurities in the CCQM-K55.a samples

Key comparison reference values (x_R) and associated standard uncertainty (u_R) were assigned for the mass fraction of each orthogonal impurity class - related substances, water, volatile organics and non-volatiles - quantified by the participants in CCQM-K55.a who used a mass balance approach to assign the estradiol content.
They are consensus values derived from the individual data supplied by each participant. The assignment method varied by impurity class and each is separately described on pages 17 to page 20 of the Final Report.

For Total Related Structure Impurities, x_R = 8.65 mg/g, u_R = 0.16 mg/g

The degree of equivalence of laboratory i with respect to the key comparison reference value is given by a pair of terms: D_i = (x_i - x_R) and U_i, its expanded uncertainty (k = 2), both expressed in mg/g, with U_i = 2(u_i² + u_R²)^1/2.

No pair-wise degrees of equivalence are computed for this comparison.

MEASURAND : Mass fraction of Water in the CCQM-K55.a samples

Key comparison reference values (x_R) and associated standard uncertainty (u_R) were assigned for the mass fraction of each orthogonal impurity class - related substances, water, volatile organics and non-volatiles - quantified by the participants in CCQM-K55.a who used a mass balance approach to assign the estradiol content.
They are consensus values derived from the individual data supplied by each participant. The assignment method varied by impurity class and each is separately described on pages 17 to page 20 of the Final Report.

For Water, x_R = 6.75 mg/g, u_R = 0.21 mg/g

The degree of equivalence of laboratory i with respect to the key comparison reference value is given by a pair of terms: D_i = (x_i - x_R) and U_i, its expanded uncertainty (k = 2), both expressed in mg/g, with U_i = 2(u_i² + u_R²)^1/2.

No pair-wise degrees of equivalence are computed for this comparison.

MEASURAND : Mass fraction of Volatile Organics in the CCQM-K55.a samples

Key comparison reference values (x_R) and associated standard uncertainty (u_R) were assigned for the mass fraction of each orthogonal impurity class - related substances, water, volatile organics and non-volatiles - quantified by the participants in CCQM-K55.a who used a mass balance approach to assign the estradiol content.
They are consensus values derived from the individual data supplied by each participant. The assignment method varied by impurity class and each is separately described on pages 17 to page 20 of the Final Report.

For Volatile Organics, x_R = 0.10 mg/g, u_R = 0.06 mg/g

The degree of equivalence of laboratory i with respect to the key comparison reference value is given by a pair of terms: D_i = (x_i - x_R) and U_i, its expanded uncertainty (k = 2), both expressed in mg/g, with U_i = 2(u_i² + u_R²)^1/2.

No pair-wise degrees of equivalence are computed for this comparison.

MEASURAND : Mass fraction of Non-Volatile Content in the CCQM-K55.a samples

Key comparison reference values (x_R) and associated standard uncertainty (u_R) were assigned for the mass fraction of each orthogonal impurity class - related substances, water, volatile organics and non-volatiles - quantified by the participants in CCQM-K55.a who used a mass balance approach to assign the estradiol content.
They are consensus values derived from the individual data supplied by each participant. The assignment method varied by impurity class and each is separately described on pages 17 to page 20 of the Final Report.

For Non-Volatile Content, x_R = 0.20 mg/g, u_R = 0.12 mg/g

The degree of equivalence of laboratory i with respect to the key comparison reference value is given by a pair of terms: D_i = (x_i - x_R) and U_i, its expanded uncertainty (k = 2), both expressed in mg/g, with U_i = 2(u_i² + u_R²)^1/2.

No pair-wise degrees of equivalence are computed for this comparison.

MEASURAND : Mass fraction of Estradiol in the CCQM-K55.a samples

x_i : result of measurement carried out by laboratory i
u_i : combined standard uncertainty of x_i

MEASURAND : Mass fraction of Related Structure Impurities in the CCQM-K55.a samples

x_i : result of measurement carried out by laboratory i
u_i : combined standard uncertainty of x_i

MEASURAND : Mass fraction of Water in the CCQM-K55.a samples

x_i : result of measurement carried out by laboratory i
u_i : combined standard uncertainty of x_i

MEASURAND : Mass fraction of Volatile Organics in the CCQM-K55.a samples

x_i : result of measurement carried out by laboratory i
u_i : combined standard uncertainty of x_i

MEASURAND : Mass fraction of Non-Volatile Content in the CCQM-K55.a samples

x_i : result of measurement carried out by laboratory i
u_i : combined standard uncertainty of x_i