| Metrology area, Sub-field | Chemistry and Biology, Nucleic Acid Analysis |
| Description | Copy number variant of HER2 in human tissue |
| Time of measurements | 2021 - 2022 |
| Status | Measurements in progress |
| Measurand | Measurand 1: copy number concentration of HER2 Measurand 2: copy number concentration of RPPH1 Measurand 3: ratio of HER2 to RPPH1 Measurand 4: copy number concentration of CEP17 (optional) Measurand 5: ratio of HER2 to CEP17 (optional) |
| Comparison type | Key Comparison |
| Consultative Committee | CCQM (Consultative Committee for Amount of Substance) |
| Conducted by | CCQM (Consultative Committee for Amount of Substance) |
| Comments | Testing of the core competencies of laboratories that deliver measurement services of copy number variant (CNV) analytes and CNV measurement has not been covered previously. Agreement was received in the October 2019 meeting of the NAWG in Torino to conduct the HER2 CNV measurement as a key comparison. This study is proposed as a follow up study to CCQM-P184 Copy number concentration and fractional abundance of a mutation (SNV or INDEL) mixed with wild-type DNA. In CCQM-P184, all participants measured single nucleotide (BRAF gene) and small deletion (EGFR gene) variants in a background of wild type genomic DNA, so CMC can be claimed for copy number concentration and copy number ratio measurements of small variants (gene regions) by digital PCR. Thus, this proposed study aims to extend participants' capability from SNV and INDEL measurement to structural variant measurement, focusing on gene copy number variation. |
| Pilot institute |
NIM
National Institute of Metrology China |
| Contact person | lianhua dong 86-10-64524959 |
| Pilot laboratory | |
|---|---|
| NIM |
National Institute of Metrology, China, APMP |
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