CCQM-K55.d : Mass fraction of Folic acid and impurity assessment

MEASURAND : Mass fraction of Folic acid in CCQM-K55.d samples

Degrees of equivalence : offset Di and expanded uncertainty (k = 2) Ui expressed in mg/g, and also in relative terms

 

CCQM-K55.d : Mass fraction of Folic acid and impurity assessment

MEASURAND : Mass fraction of total related structure impurity content in CCQM-K55.d samples

Degrees of equivalence : offset Di and expanded uncertainty (k = 2) Ui expressed in mg/g, and also in relative terms

 

CCQM-K55.d : Mass fraction of Folic acid and impurity assessment

MEASURAND : Mass fraction of Water in CCQM-K55.d samples

Degrees of equivalence : offset Di and expanded uncertainty (k = 2) Ui expressed in mg/g, and also in relative terms

 

CCQM-K55.d : Mass fraction of Folic acid and impurity assessment

MEASURAND : Mass fraction of Volatile organic content in CCQM-K55.d samples

Degrees of equivalence : offset Di and expanded uncertainty (k = 2) Ui expressed in mg/g, and also in relative terms

 

CCQM-K55.d : Mass fraction of Folic acid and impurity assessment

MEASURAND : Mass fraction of Non-volatile content in CCQM-K55.d samples

Degrees of equivalence : offset Di and expanded uncertainty (k = 2) Ui expressed in mg/g, and also in relative terms

 

CCQM-K55.d : Mass fraction of Folic acid and impurity assessment

MEASURAND : Mass fraction of Folic acid in CCQM-K55.d samples

Degrees of equivalence : offset Di and expanded uncertainty (k = 2) Ui expressed in mg/g

xR = 906.5 mg/g and 2 uR = 9.6 mg/g

Results are presented under A4 printable format in Summary Results (PDF file).

CCQM-K55.d : Mass fraction of Folic acid and impurity assessment

MEASURAND : Mass fraction of total related structure impurity content in CCQM-K55.d samples

Degrees of equivalence : offset Di and expanded uncertainty (k = 2) Ui expressed in mg/g

xR = 12.6 mg/g and 2 uR = 6.2 mg/g

Results are presented under A4 printable format in Summary Results (PDF file).

CCQM-K55.d : Mass fraction of Folic acid and impurity assessment

MEASURAND : Mass fraction of Water in CCQM-K55.d samples

Degrees of equivalence : offset Di and expanded uncertainty (k = 2) Ui expressed in mg/g

xR = 78.0 mg/g and 2 uR = 3.2 mg/g

Results are presented under A4 printable format in Summary Results (PDF file).

CCQM-K55.d : Mass fraction of Folic acid and impurity assessment

MEASURAND : Mass fraction of Volatile organic content in CCQM-K55.d samples

Degrees of equivalence : offset Di and expanded uncertainty (k = 2) Ui expressed in mg/g

xR = 0.374 mg/g and 2 uR = 0.166 mg/g

Results are presented under A4 printable format in Summary Results (PDF file).

CCQM-K55.d : Mass fraction of Folic acid and impurity assessment

MEASURAND : Mass fraction of Non-volatile content in CCQM-K55.d samples

Degrees of equivalence : offset Di and expanded uncertainty (k = 2) Ui expressed in mg/g

xR = 0.3 mg/g and 2 uR = 0.4 mg/g

Results are presented under A4 printable format in Summary Results (PDF file).

Comparison
Comparison close
CC comparison
Linked comparison
CCQM-K55.d
Metrology area, Sub-field Chemistry and Biology, Organics
Description Purity assessment of high purity organic materials: Folic acid
Time of measurements 2015 - 2016
Status Approved for equivalence
Final Reports of the comparisons
References

CCQM-K55.d Registration and progress form

Measurand Mass fraction in mg/g of Folic Acid in a sample.
Nominal value in excess of 900 mg/g
Required: Mass fraction content of main component
Optional: Mass fraction content of impurities

Transfer device Crimp-sealed amber glass vial containing 500 mg of the CCQM-K55.d comparison material as a crystalline powder.
Comparison type Key Comparison
Consultative Committee CCQM (Consultative Committee for Amount of Substance)
Conducted by CCQM (Consultative Committee for Amount of Substance)
Comments

Results published on 14 May 2018

Purity assessment of high purity organic materials: Folic acid

Pilot institute BIPM
Bureau International des Poids et Mesures
BIPM - International Organization
Contact person Steven Westwood

+33 (0) 1 45 07 70 57
First Name Last Name
wwww@ww.www +356719836 Institute 1 Institute 1 Khmelnitskiy
Pilot laboratory
BIPM

Bureau International des Poids et Mesures, BIPM - International Organization, N/A

BAM

Bundesanstalt für Materialforschung und -prüfung, Germany, EURAMET

CENAM

Centro Nacional de Metrologia, Mexico, SIM

GL

Government Laboratory, Hong Kong, China, APMP

HSA

Health Science Authority, Singapore, APMP

INMETRO

Instituto Nacional de Metrologia, Qualidade e Tecnologia, Brazil, SIM

KRISS

Korea Research Institute of Standards and Science, Korea, Republic of, APMP

LGC

Laboratory of the Government Chemist, United Kingdom, EURAMET

NIM

National Institute of Metrology, China, APMP

NIMT

National Institute of Metrology (Thailand), Thailand, APMP

NIST

National Institute of Standards and Technology, United States, SIM

NMIA

National Measurement Institute, Australia, Australia, APMP

NMIJ AIST

National Metrology Institute of Japan, Japan, APMP

NMISA

National Metrology Institute of South Africa, South Africa, AFRIMETS

NML-SIRIM

National Metrology Laboratory, SIRIM Berhad (became NMIM), Malaysia, APMP

NRC

National Research Council, Canada, SIM

UME

TÜBITAK Ulusal Metroloji Enstitüsü, Türkiye, EURAMET

VNIIM

D.I. Mendeleyev Institute for Metrology, Rosstandart, Russian Federation, COOMET

CCQM-K55.d : Mass fraction of Folic acid and impurity assessment

MEASURAND : Mass fraction of Folic acid in CCQM-K55.d samples

The key comparison reference values , xR, and associated standard uncertainty (uR) were assigned for the mass fraction of the following impurity classes: total related structure impurity content, water, volatile organic content and non-volatile content. They are consensus values derived from the individual data supplied by each participant. 

Folic acid:                      xR = 906.5 mg/g     uR = 4.8 mg/g

Total impurity content:    xR = 12.6 mg/g      uR = 3.1 mg/g

Water:                           xR = 78.0 mg/g      uR = 1.6 mg/g

Volatile organic content:  xR = 0.374 mg/g    uR = 0.083 mg/g

Non-volatile content:       xR = 0.3 mg/g        uR = 0.2 mg/g

 

The degree of equivalence of laboratory i with respect to the key comparison reference value is given by a pair of terms: Di = (xi - xR) and Ui, its expanded uncertainty (k = 2), both expressed in mg/g, with Ui = 2(ui2 + uR2)1/2.

CCQM-K55.d : Mass fraction of Folic acid and impurity assessment

MEASURAND : Mass fraction of total related structure impurity content in CCQM-K55.d samples

The key comparison reference values , xR, and associated standard uncertainty (uR) were assigned for the mass fraction of the following impurity classes: total related structure impurity content, water, volatile organic content and non-volatile content. They are consensus values derived from the individual data supplied by each participant. 

Folic acid:                      xR = 906.5 mg/g     uR = 4.8 mg/g

Total impurity content:    xR = 12.6 mg/g      uR = 3.1 mg/g

Water:                           xR = 78.0 mg/g      uR = 1.6 mg/g

Volatile organic content:  xR = 0.374 mg/g    uR = 0.083 mg/g

Non-volatile content:       xR = 0.3 mg/g        uR = 0.2 mg/g

 

The degree of equivalence of laboratory i with respect to the key comparison reference value is given by a pair of terms: Di = (xi - xR) and Ui, its expanded uncertainty (k = 2), both expressed in mg/g, with Ui = 2(ui2 + uR2)1/2.

CCQM-K55.d : Mass fraction of Folic acid and impurity assessment

MEASURAND : Mass fraction of Water in CCQM-K55.d samples

The key comparison reference values , xR, and associated standard uncertainty (uR) were assigned for the mass fraction of the following impurity classes: total related structure impurity content, water, volatile organic content and non-volatile content. They are consensus values derived from the individual data supplied by each participant. 

Folic acid:                      xR = 906.5 mg/g     uR = 4.8 mg/g

Total impurity content:    xR = 12.6 mg/g      uR = 3.1 mg/g

Water:                           xR = 78.0 mg/g      uR = 1.6 mg/g

Volatile organic content:  xR = 0.374 mg/g    uR = 0.083 mg/g

Non-volatile content:       xR = 0.3 mg/g        uR = 0.2 mg/g

 

The degree of equivalence of laboratory i with respect to the key comparison reference value is given by a pair of terms: Di = (xi - xR) and Ui, its expanded uncertainty (k = 2), both expressed in mg/g, with Ui = 2(ui2 + uR2)1/2.

CCQM-K55.d : Mass fraction of Folic acid and impurity assessment

MEASURAND : Mass fraction of Volatile organic content in CCQM-K55.d samples

The key comparison reference values , xR, and associated standard uncertainty (uR) were assigned for the mass fraction of the following impurity classes: total related structure impurity content, water, volatile organic content and non-volatile content. They are consensus values derived from the individual data supplied by each participant. 

Folic acid:                      xR = 906.5 mg/g     uR = 4.8 mg/g

Total impurity content:    xR = 12.6 mg/g      uR = 3.1 mg/g

Water:                           xR = 78.0 mg/g      uR = 1.6 mg/g

Volatile organic content:  xR = 0.374 mg/g    uR = 0.083 mg/g

Non-volatile content:       xR = 0.3 mg/g        uR = 0.2 mg/g

 

The degree of equivalence of laboratory i with respect to the key comparison reference value is given by a pair of terms: Di = (xi - xR) and Ui, its expanded uncertainty (k = 2), both expressed in mg/g, with Ui = 2(ui2 + uR2)1/2.

CCQM-K55.d : Mass fraction of Folic acid and impurity assessment

MEASURAND : Mass fraction of Non-volatile content in CCQM-K55.d samples

The key comparison reference values , xR, and associated standard uncertainty (uR) were assigned for the mass fraction of the following impurity classes: total related structure impurity content, water, volatile organic content and non-volatile content. They are consensus values derived from the individual data supplied by each participant. 

Folic acid:                      xR = 906.5 mg/g     uR = 4.8 mg/g

Total impurity content:    xR = 12.6 mg/g      uR = 3.1 mg/g

Water:                           xR = 78.0 mg/g      uR = 1.6 mg/g

Volatile organic content:  xR = 0.374 mg/g    uR = 0.083 mg/g

Non-volatile content:       xR = 0.3 mg/g        uR = 0.2 mg/g

 

The degree of equivalence of laboratory i with respect to the key comparison reference value is given by a pair of terms: Di = (xi - xR) and Ui, its expanded uncertainty (k = 2), both expressed in mg/g, with Ui = 2(ui2 + uR2)1/2.

CCQM-K55.d : Mass fraction of Folic acid and impurity assessment

MEASURAND : Mass fraction of Folic acid in CCQM-K55.d samples

xi : result of measurement carried out by laboratory i
ui : combined standard uncertainty of xi

CCQM-K55.d : Mass fraction of Folic acid and impurity assessment

MEASURAND : Mass fraction of total related structure impurity content in CCQM-K55.d samples

xi : result of measurement carried out by laboratory i
ui : combined standard uncertainty of xi

CCQM-K55.d : Mass fraction of Folic acid and impurity assessment

MEASURAND : Mass fraction of Water in CCQM-K55.d samples

xi : result of measurement carried out by laboratory i
ui : combined standard uncertainty of xi

CCQM-K55.d : Mass fraction of Folic acid and impurity assessment

MEASURAND : Mass fraction of Volatile organic content in CCQM-K55.d samples

xi : result of measurement carried out by laboratory i
ui : combined standard uncertainty of xi

CCQM-K55.d : Mass fraction of Folic acid and impurity assessment

MEASURAND : Mass fraction of Non-volatile content in CCQM-K55.d samples

xi : result of measurement carried out by laboratory i
ui : combined standard uncertainty of xi