Comparison Display

CCQM-K179

MEASURAND Mass fraction of oxytetracycline hydrochloride (OTC.HCl) salt

Degrees of equivalence represented by D_i = (x_i - x_R) and its expanded uncertainty U_i at a 95 % level of confidence, both expressed in mg/g.

Mass fraction of OTC.HCl

D_i / mg/g

Participating institutes

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CCQM-K179

MEASURAND Mass fraction of water

Degrees of equivalence represented by D_i = (x_i - x_R) and its expanded uncertainty U_i at a 95 % level of confidence, both expressed in mg/g.

Mass fraction of water

D_i / mg/g

Participating institutes

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CCQM-K179

MEASURAND Mass fraction of chloride

Degrees of equivalence represented by D_i = (x_i - x_R) and its expanded uncertainty U_i at a 95 % level of confidence, both expressed in mg/g.

Mass fraction of chloride

D_i / mg/g

Participating institutes

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CCQM-K179

MEASURAND Mass fraction of total structurally related impurities (SRI)

Degrees of equivalence represented by D_i = (x_i - x_R) and its expanded uncertainty U_i at a 95 % level of confidence, both expressed in mg/g.

Mass fraction of SRI

D_i / mg/g

Participating institutes

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CCQM-K179

MEASURAND Mass fraction of oxytetracycline hydrochloride (OTC.HCl) salt

Degrees of equivalence represented by D_i = (x_i - x_R) and its expanded uncertainty U_i at a 95 % level of confidence, both expressed in mg/g.

LAB_i	D_i	U_neg,i	U_pos,i
	mg/g	mg/g	mg/g
HSA	-15.9	18.5
NMISA	4.3	18.2
BIPM	-3.3	13.7
NMIJ	-1.2	13.4
NMIA	1.3	13.9
NIM	-0.2	15.4
GL	5.6	14.3
INMETRO	5.2	13.4
EXHM/GCSL-EIM	6.0	15.1
UME	24.8	20.3
KRISS	12.7	17.5
KIMIA	42.3	15.0
VNIIM	64.6	11.7
NIMT	53.5	50.0
NMLPHIL	36.0	15.4

Participating institutes

CCQM-K179

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CCQM-K179

MEASURAND Mass fraction of water

Degrees of equivalence represented by D_i = (x_i - x_R) and its expanded uncertainty U_i at a 95 % level of confidence, both expressed in mg/g.

LAB_i	D_i	U_neg,i	U_pos,i
	mg/g	mg/g	mg/g
HSA	2.3	9.8
NMISA	-6.6	7.7
BIPM	6.2	9.6
NMIJ	2.9	8.1
NMIA	3.4	9.9
NIM	-14.2	10.0
GL	-1.3	13.3
INMETRO	-2.3	6.7
EXHM/GCSL-EIM	1.2	6.5
UME	-30.7	6.2
KRISS	-26.0	7.0
KIMIA	-34.7	9.9
VNIIM	-41.8	6.6
NIMT	-45.1	33.5
NMLPHIL	-46.1	7.2

Participating institutes

CCQM-K179

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CCQM-K179

MEASURAND Mass fraction of chloride

Degrees of equivalence represented by D_i = (x_i - x_R) and its expanded uncertainty U_i at a 95 % level of confidence, both expressed in mg/g.

LAB_i	D_i	U_neg,i	U_pos,i
	mg/g	mg/g	mg/g
HSA	0.9	6.6
NMISA	-5.0	5.7
BIPM	0.0	5.0
NMIJ	-0.5	4.9
NMIA	0.5	11.6
NIM	1.6	5.1
GL	1.2	6.5
INMETRO	4.1	5.3
EXHM/GCSL-EIM	-1.1	5.5
UME	-2.2	5.2
KRISS	1.1	5.0
KIMIA	8.8	6.7
VNIIM	9.3	6.3
NIMT	-1.9	10.6
NMLPHIL	5.1	7.6

Participating institutes

CCQM-K179

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CCQM-K179

MEASURAND Mass fraction of total structurally related impurities (SRI)

Degrees of equivalence represented by D_i = (x_i - x_R) and its expanded uncertainty U_i at a 95 % level of confidence, both expressed in mg/g.

LAB_i	D_i	U_neg,i	U_pos,i
	mg/g	mg/g	mg/g
HSA	2.7	15.3
NMISA	23.7	15.0
BIPM	-2.9	10.3
NMIJ	-6.2	11.3
NMIA	-4.5	10.1
NIM	8.9	10.8
GL	-8.7	11.0
INMETRO	-7.4	11.0
EXHM/GCSL-EIM	-5.3	11.2
UME	9.3	10.1
KRISS	-2.4	10.1
KIMIA	-4.3	11.4
VNIIM	-20.6	10.2
NIMT	-7.1	10.1
NMLPHIL	8.5	13.9

Participating institutes

CCQM-K179

Comparison

Comparison close

CCQM-K179

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Information & contact
Participants

Metrology area, Sub-field	Chemistry and Biology, Organics
Description	Mass fraction in mg/g of oxytetracycline hydrochloride salt in the oxytetracycline hydrochloride comparison material
Time of measurements	2022 - 2023
Status	Approved for equivalence

Final Reports of the comparisons	Metrologia 2025 62 Tech. Suppl. 08013
Measurand	Mass fraction of oxytetracycline hydrochloride salt > 500 mg/g
Parameters	Mass fraction content of main component (required). Mass fraction content of impurity content (optional)
Transfer device	Screw-capped amber glass vials containing 500 mg of the comparison material as a crystalline powder.

Comparison type	Key Comparison
Consultative Committee	CCQM (Consultative Committee for Amount of Substance)
Conducted by	BIPM (Bureau International des Poids et Mesures)
Comments	Track C comparison for Primary Reference Services authorized by the OAWG.
Pilot institute	BIPM Bureau International des Poids et Mesures BIPM - International Organization
Contact person	Gustavo MARTOS

Pilot laboratory
BIPM	Bureau International des Poids et Mesures, BIPM - International Organization, N/A

BVL	Bundesamt für Verbraucherschutz und Lebensmittelsicherheit, Germany, EURAMET

EXHM/GCSL-EIM

National Laboratory of Chemical Metrology/GCSL - Hellenic Institute of Metrology, Greece, EURAMET

GL	Government Laboratory, Hong Kong, China, APMP

HSA	Health Science Authority, Singapore, APMP

INMETRO

Instituto Nacional de Metrologia, Qualidade e Tecnologia, Brazil, SIM

KIMIA

Department of Chemistry Malaysia, Malaysia, APMP

KRISS

Korea Research Institute of Standards and Science, Korea, Republic of, APMP

NIM	National Institute of Metrology, China, APMP

NIMT	National Institute of Metrology (Thailand), Thailand, APMP

NMIA	National Measurement Institute, Australia, Australia, APMP

NMIJ AIST

National Metrology Institute of Japan, Japan, APMP

NMISA

National Metrology Institute of South Africa, South Africa, AFRIMETS

NMLPHIL

National Metrology Laboratory of the Philippines, Philippines, APMP

UME	TÜBITAK Ulusal Metroloji Enstitüsü, Türkiye, EURAMET

VNIIM

D.I. Mendeleyev Institute for Metrology, Rosstandart, Russian Federation, COOMET

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CCQM-K179

MEASURAND Mass fraction of oxytetracycline hydrochloride (OTC.HCl) salt

The key comparison reference value x_R and its associated standard uncertainty u_R are based on the key comparison reference value of the parallel key comparison CCQM-K148.b conducted on the same material, which was multiplied by the ratio of the molar masses of the OTC.HCl (salt) to the OTC (free base) according to Eq. 1 of the CCQM-K179 Final report, with exclusions.

x_R = 854.7 mg/g u_R = 5.7 mg/g

The degree of equivalence of laboratory i relative to the key comparison reference value x_R is given by a pair of terms, both expressed in mg/g:

D_i = (x_i - x_R) and its expanded uncertainty U_i at a 95 % level of confidence where U_i = 2 (u_i² + u_R²)^1/2 .

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CCQM-K179

MEASURAND Mass fraction of water

The key comparison reference value x_R and its associated standard uncertainty u_R were based on the CCQM-K148.b as described in page 18 of the CCQM-K179 Final report.

x_R = 104.1 mg/g u_R = 1.2 mg/g

The degree of equivalence of laboratory i relative to the key comparison reference value x_R is given by a pair of terms, both expressed in mg/g:

D_i = (x_i - x_R) and its expanded uncertainty U_i at a 95 % level of confidence where U_i = 2 (u_i² + u_R²)^1/2 .

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CCQM-K179

MEASURAND Mass fraction of chloride

The key comparison reference value x_R and its associated standard uncertainty u_R were based on the CCQM-K148.b as described in page 18 of the CCQM-K179 Final report.

x_R = 63.5 mg/g u_R = 0.9 mg/g

The degree of equivalence of laboratory i relative to the key comparison reference value x_R is given by a pair of terms, both expressed in mg/g:

D_i = (x_i - x_R) and its expanded uncertainty U_i at a 95 % level of confidence where U_i = 2 (u_i² + u_R²)^1/2 .

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CCQM-K179

MEASURAND Mass fraction of total structurally related impurities (SRI)

The key comparison reference value x_R and its associated standard uncertainty u_R were based on the CCQM-K148.b as described in page 18 of the CCQM-K179 Final report.

x_R = 38.3 mg/g u_R = 5.0 mg/g

The degree of equivalence of laboratory i relative to the key comparison reference value x_R is given by a pair of terms, both expressed in mg/g:

D_i = (x_i - x_R) and its expanded uncertainty U_i at a 95 % level of confidence where U_i = 2 (u_i² + u_R²)^1/2 .

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CCQM-K179

MEASURAND Mass fraction of oxytetracycline hydrochloride (OTC.HCl) salt

To add comparison identifier

x_i measured mass fraction reported by laboratory i, Lab_i

u_i combined standard uncertainty of x_i

Lab_i	x_i	u_i
Lab_i	mg/g	mg/g
HSA	838.8	7.3
BIPM	851.4	3.9
NMIJ	853.5	3.6
NIM	854.5	5.2
NMIA	856	4
NMISA	859	7.1
INMETRO	859.9	3.6
GL	860.3	4.4
EXHM/GCSL-EIM	860.64	5.04
KRISS	867.4	6.7
UME	879.5	8.4
NMLPHIL	890.7	5.2
KIMIA	897	4.95
NIMT	908.2	24.35
VNIIM	919.3	1.5

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CCQM-K179

MEASURAND Mass fraction of water

x_i measured mass fraction reported by laboratory i, Lab_i

u_i combined standard uncertainty of x_i

Lab_i	x_i	u_i
Lab_i	mg/g	mg/g
HSA	106.4	4
BIPM	110.3	3.7
NMIJ	107.04	2.71
NIM	89.9	4.09
NMIA	107.5	4
NMISA	97.5	2.26
INMETRO	101.8	1.2
GL	102.8	6
EXHM/GCSL-EIM	105.33	0.66
KRISS	78.1	1.8
UME	73.4	0.5
NMLPHIL	58	1.91
KIMIA	69.42	4.02
NIMT	59.07	16.64
VNIIM	62.34	1.21

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CCQM-K179

MEASURAND Mass fraction of chloride

x_i measured mass fraction reported by laboratory i, Lab_i

u_i combined standard uncertainty of x_i

Lab_i	x_i	u_i
Lab_i	mg/g	mg/g
NIMT	61.66	4.89
NMISA	58.5	1.5
EXHM/GCSL-EIM	62.4	1.36
NMIJ	63.07	0.07
BIPM	2.67	0.50
KRISS	64.6	0.4
NMIA	64	5.5
GL	64.7	2.2
NIM	2.62	0.028
HSA	64.4	2.3
NMLPHIL	68.6	3
INMETRO	1.8	1.1
VNIIM	72.86	2.22
KIMIA	72.33	2.42

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CCQM-K179

MEASURAND Mass fraction of total structurally related impurities (SRI)

x_i measured mass fraction reported by laboratory i, Lab_i

u_i combined standard uncertainty of x_i

Lab_i	x_i	u_i
Lab_i	mg/g	mg/g
VNIIM*	17.75	0.93
GL	32	2.5
INMETRO	33.4	2.4
NIMT*	31.23	0.71
EXHM/GCSL-EIM	34.44	2.62
NMIJ	34.56	2.8
NMIA	36.5	0.7
KIMIA*	33.96	2.67
KRISS	38.1	0.7
BIPM*	35.4	1.2
HSA	44.3	8.6
NIM	48.38	2.1
NMLPHIL*	46.8	4.8
UME*	47.6	0.4
NMISA*	62	5.6

Participants marked with * reported the structurally related impurities as free base forms so the SRI hydrochloride salt content was estimated assuming 1:1 stoichiometry and using the impurities molar masses or the OTC molar mass for unidentified impurities (see page 10 of the CCQM-K176 Final report).

KCDB

CIPM MRA

CLASSIFICATION OF SERVICES

Key and supplementary comparisons - Print out