CCQM-K148.b
MEASURAND Mass fraction of oxytetracycline free base (OTC) in oxytetracycline hydrochloride (OTC.HCl)
Degrees of equivalence represented by Di = (xi - xR) and its expanded uncertainty Ui at a 95 % level of confidence, both expressed in mg/g.
CCQM-K148.b
MEASURAND Mass fraction of water
Degrees of equivalence represented by Di = (xi - xR) and its expanded uncertainty Ui at a 95 % level of confidence, both expressed in mg/g.
CCQM-K148.b
MEASURAND Mass fraction of chloride
Degrees of equivalence represented by Di = (xi - xR) and its expanded uncertainty Ui at a 95 % level of confidence, both expressed in mg/g.
CCQM-K148.b
MEASURAND Mass fraction of total structurally related impurities (SRI)
Degrees of equivalence represented by Di = (xi - xR) and its expanded uncertainty Ui at a 95 % level of confidence, both expressed in mg/g.
CCQM-K148.b
MEASURAND Mass fraction of oxytetracycline free base (OTC) in oxytetracycline hydrochloride (OTC.HCl)
Degrees of equivalence represented by Di = (xi - xR) and its expanded uncertainty Ui at a 95 % level of confidence, both expressed in mg/g.
| LABi | Di | Uneg,i | Upos,i | |
|---|---|---|---|---|
mg/g |
mg/g |
mg/g |
||
| HSA | -14.9 | 17.3 | ||
| NMISA | -12.0 | 16.2 | ||
| NRC | -5.0 | 28.0 | ||
| BIPM | -2.7 | 12.2 | ||
| NMIJ | -0.9 | 12.6 | ||
| NMIA | 0.0 | 17.5 | ||
| NIM | 0.6 | 14.3 | ||
| GL | 4.5 | 13.6 | ||
| INMETRO | 4.7 | 12.4 | ||
| EXHM/GCLS-EIM | 5.5 | 14.0 | ||
| BAM | 6.9 | 10.6 | ||
| LGC | 13.6 | 11.4 | ||
| NIST | 14.0 | 11.6 | ||
| UME | 24.5 | 28.0 | ||
| KRISS | 27.4 | 11.6 | ||
| KIMIA | 35.2 | 15.2 | ||
| BVL | 41.4 | 14.7 | ||
| VNIIM | 52.5 | 11.8 | ||
| NIMT | 53.8 | 46.7 | ||
| INRIM | 69.7 | 12.1 |
CCQM-K148.b
MEASURAND Mass fraction of water
Degrees of equivalence represented by Di = (xi - xR) and its expanded uncertainty Ui at a 95 % level of confidence, both expressed in mg/g.
| LABi | Di | Uneg,i | Upos,i | |
|---|---|---|---|---|
mg/g |
mg/g |
mg/g |
||
| HSA | 2.3 | 9.8 | ||
| NMISA | -6.6 | 7.7 | ||
| BIPM | 6.2 | 9.6 | ||
| NMIJ | 2.9 | 8.1 | ||
| NMIA | 3.4 | 9.9 | ||
| NIM | -14.2 | 10.0 | ||
| GL | -1.3 | 13.3 | ||
| INMETRO | -2.3 | 6.7 | ||
| EXHM/GCSL-EIM | 1.2 | 6.5 | ||
| LGC | -2.4 | 10.1 | ||
| NIST | 0.3 | 6.6 | ||
| UME | -30.7 | 6.2 | ||
| KRISS | -26.0 | 7.0 | ||
| KIMIA | -34.7 | 9.9 | ||
| BVL | -50.2 | 7.5 | ||
| VNIIM | -41.8 | 6.6 | ||
| NIMT | -45.1 | 33.5 |
CCQM-K148.b
MEASURAND Mass fraction of chloride
Degrees of equivalence represented by Di = (xi - xR) and its expanded uncertainty Ui at a 95 % level of confidence, both expressed in mg/g.
| LABi | Di | Uneg,i | Upos,i | |
|---|---|---|---|---|
mg/g |
mg/g |
mg/g |
||
| HSA | 0.9 | 6.6 | ||
| NMISA | -5.0 | 5.7 | ||
| BIPM | 0.0 | 5.0 | ||
| NMIJ | -0.5 | 4.9 | ||
| NMIA | 0.5 | 11.6 | ||
| NIM | 1.6 | 5.1 | ||
| GL | 1.2 | 6.5 | ||
| INMETRO | 4.1 | 5.3 | ||
| EXHM/GCSL-EIM | -1.1 | 5.5 | ||
| LGC | 0.9 | 5.8 | ||
| UME | -2.2 | 5.2 | ||
| KRISS | 1.1 | 5.0 | ||
| KIMIA | 8.8 | 6.7 | ||
| BVL | 3.0 | 5.5 | ||
| VNIIM | 9.3 | 6.3 | ||
| NIMT | -1.9 | 10.6 |
CCQM-K148.b
MEASURAND Mass fraction of total structurally related impurities (SRI)
Degrees of equivalence represented by Di = (xi - xR) and its expanded uncertainty Ui at a 95 % level of confidence, both expressed in mg/g.
| LABi | Di | Uneg,i | Upos,i | |
|---|---|---|---|---|
mg/g |
mg/g |
mg/g |
||
| HSA | 2.7 | 15.3 | ||
| NMISA | 23.7 | 15.0 | ||
| NRC | 8.7 | 22.4 | ||
| BIPM | -2.9 | 10.3 | ||
| NMIJ | -6.2 | 11.3 | ||
| NMIA | -4.5 | 10.1 | ||
| NIM | 8.9 | 10.8 | ||
| GL | -8.7 | 11.0 | ||
| INMETRO | -7.4 | 11.0 | ||
| EXHM/GCSL-EIM | -5.3 | 11.2 | ||
| UME | 9.3 | 10.1 | ||
| KRISS | -2.4 | 10.1 | ||
| KIMIA | -4.3 | 11.4 | ||
| BVL | 5.7 | 12.2 | ||
| VNIIM | -20.6 | 10.2 | ||
| NIMT | -7.1 | 10.1 |
| Metrology area, Sub-field | Chemistry and Biology, Organics |
| Description | Mass fraction in mg/g of oxytetracycline (free base) in the oxytetracycline hydrochloride CCQM-K148.b comparison material |
| Time of measurements | 2022 - 2023 |
| Status | Approved for equivalence |
| Final Reports of the comparisons | |
| Measurand | Oxytetracycline mass fraction > 500 mg/g |
| Parameters | Mass fraction content of main component (required). Mass fraction content of impurity content (optional) |
| Transfer device | Screw-capped amber glass vials containing 500 mg of the CCQM-K148.b comparison material as a crystalline powder |
| Comparison type | Key Comparison |
| Consultative Committee | CCQM (Consultative Committee for Amount of Substance) |
| Conducted by | BIPM (Bureau International des Poids et Mesures) |
| Comments | Track A comparison for Primary Reference Services authorized by the OAWG |
| Pilot institute |
BIPM
Bureau International des Poids et Mesures BIPM - International Organization |
| Contact person | Gustavo MARTOS |
| Pilot laboratory | |
|---|---|
| BIPM |
Bureau International des Poids et Mesures, BIPM - International Organization, N/A |
| BAM |
Bundesanstalt für Materialforschung und -prüfung, Germany, EURAMET |
| BVL |
Bundesamt für Verbraucherschutz und Lebensmittelsicherheit, Germany, EURAMET |
| EXHM/GCSL-EIM |
National Laboratory of Chemical Metrology/GCSL - Hellenic Institute of Metrology, Greece, EURAMET |
| GL |
Government Laboratory, Hong Kong, China, APMP |
| HSA |
Health Science Authority, Singapore, APMP |
| INMETRO |
Instituto Nacional de Metrologia, Qualidade e Tecnologia, Brazil, SIM |
| INRIM |
Istituto Nazionale di Ricerca Metrologica, Italy, EURAMET |
| KIMIA |
Department of Chemistry Malaysia, Malaysia, APMP |
| KRISS |
Korea Research Institute of Standards and Science, Korea, Republic of, APMP |
| LGC |
Laboratory of the Government Chemist, United Kingdom, EURAMET |
| NIM |
National Institute of Metrology, China, APMP |
| NIMT |
National Institute of Metrology (Thailand), Thailand, APMP |
| NIST |
National Institute of Standards and Technology, United States, SIM |
| NMIA |
National Measurement Institute, Australia, Australia, APMP |
| NMIJ AIST |
National Metrology Institute of Japan, Japan, APMP |
| NMISA |
National Metrology Institute of South Africa, South Africa, AFRIMETS |
| NMLPHIL |
National Metrology Laboratory of the Philippines, Philippines, APMP |
| NRC |
National Research Council, Canada, SIM |
| UME |
TÜBITAK Ulusal Metroloji Enstitüsü, Türkiye, EURAMET |
| VNIIM |
D.I. Mendeleyev Institute for Metrology, Rosstandart, Russian Federation, COOMET |
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Please, select items to be printed out, then click on "OK" :
CCQM-K148.b
MEASURAND Mass fraction of oxytetracycline free base (OTC) in oxytetracycline hydrochloride (OTC.HCl)
The key comparison reference value xR and its associated standard uncertainty uR were calculated using the mass balance approach from the results of participants with exclusions as described in page 23 to 27 of the CCQM-K148.b Final Report.
xR = 792.0 mg/g uR = 5.2 mg/g
The degree of equivalence of laboratory i relative to the key comparison reference value xR is given by a pair of terms, both expressed in mg/g:
Di = (xi - xR) and its expanded uncertainty Ui at a 95 % level of confidence where Ui = 2 (ui2 + uR2)1/2 .
CCQM-K148.b
MEASURAND Mass fraction of water
The key comparison reference value xR and its associated standard uncertainty uR were computed using the Hierarchical Bayes random effects model, from the results of participants with exclusions as described in page 23 to 27 of the CCQM-K148.b Final Report.
xR = 104.1 mg/g uR = 1.2 mg/g
The degree of equivalence of laboratory i relative to the key comparison reference value xR is given by a pair of terms, both expressed in mg/g:
Di = (xi - xR) and its expanded uncertainty Ui at a 95 % level of confidence where Ui = 2 (ui2 + uR2)1/2 .
CCQM-K148.b
MEASURAND Mass fraction of chloride
The key comparison reference value xR and its associated standard uncertainty uR were computed using the Hierarchical Bayes random effects model, from the results of participants with exclusions as described in page 23 to 27 of the CCQM-K148.b Final Report.
xR = 63.5 mg/g uR = 0.9 mg/g
The degree of equivalence of laboratory i relative to the key comparison reference value xR is given by a pair of terms, both expressed in mg/g:
Di = (xi - xR) and its expanded uncertainty Ui at a 95 % level of confidence where Ui = 2 (ui2 + uR2)1/2 .
CCQM-K148.b
MEASURAND Mass fraction of total structurally related impurities (SRI)
The key comparison reference value xR and its associated standard uncertainty uR were estimated from the average of the highest and lowest values of the selected dataset (rectangular probability distribution) as described in page 23 to 27 of the CCQM-K148.b Final Report.
xR = 38.3 mg/g uR = 5.0 mg/g
The degree of equivalence of laboratory i relative to the key comparison reference value xR is given by a pair of terms, both expressed in mg/g:
Di = (xi - xR) and its expanded uncertainty Ui at a 95 % level of confidence where Ui = 2 (ui2 + uR2)1/2 .
CCQM-K148.b
MEASURAND Mass fraction of oxytetracycline free base (OTC) in oxytetracycline hydrochloride (OTC.HCl)
xi measured mass fraction reported by laboratory i, Labi
ui combined standard uncertainty of xi
| Labi | xi | ui | |
| mg/g | mg/g | ||
| HSA | 777.1 | 6.9 | |
| NMISA | 780 | 6.2 | |
| NRC | 787 | 13 | |
| BIPM | 789.3 | 3.1 | |
| NMIJ | 791.1 | 3.5 | |
| NMIA | 792 | 7 | |
| NIM | 792.6 | 4.9 | |
| GL | 796.5 | 4.3 | |
| INMETRO | 796.7 | 3.3 | |
| EXHM/GCLS-EIM | 797.5 | 4.67 | |
| BAM | 798.9 | 0.8 | |
| LGC | 805.6 | 2.3 | |
| NIST | 806 | 2.5 | |
| UME | 816.5 | 13 | |
| KRISS | 819.4 | 2.5 | |
| KIMIA | 827.12 | 5.48 | |
| BVL | 833.33 | 5.14 | |
| VNIIM | 844.5 | 2.7 | |
| NIMT | 845.8 | 22.8 | |
| INRIM | 861.7 | 3.1 |
CCQM-K148.b
MEASURAND Mass fraction of water
xi mass fraction reported by laboratory i, Labi
ui combined standard uncertainty of xi
| Labi | xi | ui | |
| mg/g | mg/g | ||
| HSA | 106.4 | 4.0 | |
| NMISA | 98 | 2.3 | |
| BIPM | 110 | 4 | |
| NMIJ | 107.0 | 2.7 | |
| NMIA | 107.5 | 4.0 | |
| NIM | 90 | 4 | |
| GL | 102.8 | 6.0 | |
| INMETRO | 101.8 | 1.2 | |
| EXHM/GCSL-EIM | 105.3 | 0.7 | |
| LGC | 101.8 | 4.07 | |
| NIST | 104.4 | 0.8 | |
| UME | 73.4 | 0.5 | |
| KRISS | 78 | 1.8 | |
| KIMIA | 69.4 | 4 | |
| BVL | 54.0 | 2.1 | |
| VNIIM | 62.34 | 1.21 |
CCQM-K148.b
MEASURAND Mass fraction of chloride
xi measured mass fraction reported by laboratory i, Labi
ui combined standard uncertainty of xi
| Labi | xi | ui | |
| mg/g | mg/g | ||
| HSA | 64.4 | 2.3 | |
| NMISA | 59 | 1.5 | |
| BIPM | 64 | 0 | |
| NMIJ | 63.1 | 0.1 | |
| NMIA | 64.0 | 5.5 | |
| NIM | 65 | 1 | |
| GL | 64.7 | 2.2 | |
| INMETRO | 67.6 | 1.1 | |
| EXHM/GCSL-EIM | 62.4 | 1.4 | |
| LGC | 64.4 | 1.60 | |
| UME | 61.3 | 0.8 | |
| KRISS | 64.6 | 0.4 | |
| KIMIA | 72 | 2.4 | |
| BVL | 66.6 | 1 | |
| VNIIM | 72.9 | 2.2 | |
| NIMT | 61.66 | 4.89 |
CCQM-K148.b
MEASURAND Mass fraction of total structurally related impurities (SRI)
xi mass fraction reported by laboratory i, Labi
ui combined standard uncertainty of xi
| Labi | xi | ui | |
| mg/g | mg/g | ||
| HSA | 41.0 | 5.8 | |
| NMISA | 62 | 5.6 | |
| NRC | 47 | 10 | |
| BIPM | 35.4 | 1.2 | |
| NMIJ | 32.1 | 2.6 | |
| NMIA | 34 | 1 | |
| NIM | 47.2 | 2.0 | |
| GL | 29.6 | 2.3 | |
| INMETRO | 30.9 | 2.3 | |
| EXHM/GCSL-EIM | 33.0 | 2.51 | |
| UME | 47.6 | 0.4 | |
| KRISS | 35.9 | 0.7 | |
| KIMIA | 34 | 2.7 | |
| BVL | 44.0 | 3 | |
| VNIIM | 17.8 | 0.9 | |
| NIMT | 31.23 | 0.71 |
