MEASURAND Mass fraction of OXT
xR = 787.2 mg/g uR = 5.3 mg/g
Degrees of equivalence represented by Di and its expanded uncertainty Ui at a 95 % level of confidence, both expressed in mg/g.
MEASURAND Mass fraction of total peptide related impurities
xR = 31.6 mg/g uR = 0.7 mg/g
Degrees of equivalence represented by Di and its expanded uncertainty Ui at a 95 % level of confidence, both expressed in mg/g.
MEASURAND Mass fraction of OXT
xR = 787.2 mg/g uR = 5.3 mg/g
Degrees of equivalence represented by Di and its expanded uncertainty Ui at a 95 % level of confidence, both expressed in mg/g.
| LABi | Di | Uneg,i | Upos,i | |
|---|---|---|---|---|
mg/g |
mg/g |
mg/g |
||
| INMETRO (PICAA/PICqNMR) | -6.2 | 20.9 | ||
| NMIM (qNMR) | 199.8 | 13.3 | ||
| NIM (Mass Balance) | 9.3 | 12.5 | ||
| BIPM (Mass Balance) | 12.6 | 17.7 | ||
| LGC (PICAA) | -20.2 | 33.7 | ||
| NMIJ (PICAA) | -20.9 | 27.3 | ||
| NRC (PICqNMR) | -0.6 | 23.3 | ||
| UME (PICAA) | -14.1 | 53.9 |
MEASURAND Mass fraction of total peptide related impurities
xR = 31.6 mg/g uR = 0.7 mg/g
Degrees of equivalence represented by Di and its expanded uncertainty Ui at a 95 % level of confidence, both expressed in mg/g.
| LABi | Di | Uneg,i | Upos,i | |
|---|---|---|---|---|
mg/g |
mg/g |
mg/g |
||
| INMETRO (PICAA/PICqNMR) | -4.3 | 1.5 | ||
| NIM (Mass Balance) | 0.8 | 3.4 | ||
| BIPM (Mass Balance) | -0.5 | 2.2 | ||
| LGC (PICAA) | 3.6 | 5.8 | ||
| NMIJ (PICAA) | 2.8 | 4.9 | ||
| NRC (PICqNMR) | -3.4 | 11.1 | ||
| UME (PICAA) | 15.1 | 2.3 |
| Metrology area, Sub-field | Chemistry and Biology, Protein Analysis |
| Description | Peptide purity determination - synthetic oxytocin (OXT) |
| Time of measurements | 2018 |
| Status | Approved for equivalence |
| Final Reports of the comparisons | |
| Measurand | Mass fraction of oxytocin in the material (in mg/g) |
| Transfer device | Dedicated samples |
| Comparison type | Key Comparison |
| Consultative Committee | CCQM (Consultative Committee for Amount of Substance) |
| Conducted by | CCQM (Consultative Committee for Amount of Substance) |
| Comments | Results published on 23 July 2020 |
| Pilot institute |
BIPM
Bureau International des Poids et Mesures BIPM - International Organization |
| Contact person | R. Josephs +33 (0) 1 45 07 70 55 |
| Pilot laboratory | |
|---|---|
| BIPM |
Bureau International des Poids et Mesures, BIPM - International Organization, N/A |
| INMETRO |
Instituto Nacional de Metrologia, Qualidade e Tecnologia, Brazil, SIM |
| LGC |
Laboratory of the Government Chemist, United Kingdom, EURAMET |
| NIM |
National Institute of Metrology, China, APMP |
| NMIJ AIST |
National Metrology Institute of Japan, Japan, APMP |
| NMIM |
National Metrology Institute of Malaysia, Malaysia, APMP |
| NRC |
National Research Council, Canada, SIM |
| UME |
TÜBITAK Ulusal Metroloji Enstitüsü, Türkiye, EURAMET |
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MEASURAND Mass fraction of OXT
The key comparison reference value xR and its associated standard uncertainty uR are based on the DerSimonian-Laird variance-weighted mean (DSL) of the participants' results excluding those of NMIM as reported on page 32 of the Final Report.
xR = 787.2 mg/g uR = 5.3 mg/g
The degree of equivalence of laboratory i relative to the key comparison reference value xR is given by a pair of terms, both expressed in mg/g:
Di = (xi - xR) and its expanded uncertainty Ui at a 95 % level of confidence where Ui = 2 (uR2 + ui2)1/2.
MEASURAND Mass fraction of total peptide related impurities
The key comparison reference value xR and its associated standard uncertainty uR are based on the weighted mean approach of the participants' results excluding those of INMETRO, NMIJ and UME as reported on page 28 of the Final Report.
xR = 31.6 mg/g uR = 0.7 mg/g
The degree of equivalence of laboratory i relative to the key comparison reference value xR is given by a pair of terms, both expressed in mg/g:
Di = (xi - xR) and its expanded uncertainty Ui at a 95 % level of confidence where Ui = 2 (uR2 + ui2)1/2.
MEASURAND Mass fraction of OXT
xi measurement value reported by participant laboratory i, Lab i
ui combined standard uncertainty of xi
| Labi | xi | ui | |
| mg/g | mg/g | ||
| BIPM | 799.8 | 7.1 | |
| NIM | 796.5 | 3.3 | |
| NMIM | 987 | 4 | |
| NRC | 786.6 | 10.4 | |
| INMETRO | 781 | 9 | |
| UME | 773.09 | 26.42 | |
| LGC | 767 | 16 | |
| NMIJ | 766.3 | 12.6 |
MEASURAND Mass fraction of total peptide related impurities
xi measurement value reported by participant laboratory i, Lab i
ui combined standard uncertainty of xi
| Labi | xi | ui | |
| mg/g | mg/g | ||
| BIPM | 31.1 | 0.8 | |
| NIM | 32.43 | 1.52 | |
| NMIM | - | - | |
| NRC | 28.2 | 5.5 | |
| INMETRO | 27.3 | 0.3 | |
| UME | 46.7 | 0.94 | |
| LGC | 35.2 | 2.8 | |
| NMIJ | 34.4 | 2.4 |
