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measurement methods/procedures and services

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Result of the search: list of reference measurement methods/procedures

Isotope dilution mass spectrometry methods for amyloid beta 1-42 in other
2D-UPLC-tandem mass spectrometric method for analysis of amyloid beta 1-42 in human CSF
Applicable matrice(s) frozen human cerebrospinal fluid (CSF)
Full description of technique(s) Liquid chromatography tandem mass spectrometry, solid phase extraction
Quantity Mass concentration
Applicable range 100 pg/mL to 3000 pg/mL
Expected uncertainty
(level of confidence 95%)
14.3 pg/mL to 355.2 pg/mL
Reference(s) Qualification of a surrogate matrix-based absolute quantification method for Amyloid 42 in human cerebrospinal fluid using 2D UPLC-Tandem Mass Spectrometry, Korecka M et al., Journal of Alzheimer's Disease (JAD), 2014, 41(2), 441-451
Comparability assessment study(ies) Clinical comparison with immunoassay as cited in: Korecka M et al., JAD, 2014, 41(2), 441-451
Round robin test on quantification of amyloid--1-42 in cerebrospinal fluid by mass spectrometry, Pannee J et al., Alzheimer's and Dementia, 2016, 12(1), 55-59
Comment(s) The reference measurement method, C12RMP1, for quantification of A42 in cerebrospinal fluid was developed and validated by the Biomarker Research Laboratory of Perelman School of Medicine, University of Pennsylvania
JCTLM DB identification number C12RMP1
Mass spectrometry-based candidate reference measurement procedure for quantification of A42 in cerebrospinal fluid
Applicable matrice(s) human cerebrospinal fluid
Full description of technique(s) Isotope dilution mass spectrometry
Quantity Mass concentration
Applicable range 150 pg/ml to 4000 pg/ml
Expected uncertainty
(level of confidence 95%)
15.7 %
Reference(s) Mass spectrometry-based candidate reference measurement procedure for quantification of A42 in cerebrospinal fluid, A. Leinenbach et al. on behalf of the IFCC Scientific Division Working Group on CSF proteins (WG-CSF)
Clin. Chem., 2014, 60(7), 987-994
Comparability assessment study(ies) See reference cited above for comparability assessment study
Comment(s) The reference measurement procedure, C11 RMP9, for quantification of A42 in cerebrospinal fluid was developed and validated by Roche Diagnostics GmbH in collaboration with the University of Gothenburg
JCTLM DB identification number C11RMP9

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