Scientists from National Metrology Institutes and the BIPM working within the Protein Analysis Working Group (PAWG) of the Consultative Committee for Amount of Substance: Metrology in Chemistry and Biology (CCQM) have been awarded a CITAC Best Paper Award 2019, for their publication on Establishment of measurement traceability for peptide and protein quantification through rigorous purity assessment - a review, which was published in the Metrologia Focus Issue on Advances in Metrology in Chemistry and Biology.
The review concentrates on the progress made in establishing methodologies and capabilities the for the analysis of the mass fraction content of pure peptide /protein substances or solutions thereof. Accurately and rigorously characterized pure peptide primary calibrators are essential for the development of Reference Measurement Systems (RMS) for clinical chemistry and laboratory medicine as the basis of a calibration hierarchy for diagnostic tests performed in medical laboratories. Analytes and the related conditions or diseases for which RMSs have been or are being developed include: angiotensins for hypertension; HbA1c, insulin and C-peptide for diabetes; and parathyroid hormone for chronic kidney disease.
The mission of the Cooperation on International Traceability in Analytical Chemistry (CITAC) is to improve traceability of the results of chemical measurement everywhere in the world and to ensure that analytical measurements made in different countries and/or at different times are comparable.
Josephs R.D., Martos G., Li M., Wu L., Melanson J.E., Quaglia M., Beltrão P.J., Prevoo-Franzsen D., Boeuf A., Delatour V., Öztug M., Henrion A., Jeong J.-S. and Park S.-R. Establishment of measurement traceability for peptide and protein quantification through rigorous purity assessment - a review, 2019, Metrologia, 56, 044006