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Quantitative NMR (qNMR) for organic purity measurements

The BIPM's qNMR facility will be installed in October 2014. This follows on from a collaborative agreement between the BIPM and NMIJ (Japan) related to the development and application of quantitative NMR (qNMR) for organic primary calibrator comparisons. This collaborative agreement will support the BIPM's activity in coordinating key comparisons and lead to improved qNMR analytical methods and procedures being made available to all Member States and Associates of the CGPM. qNMR is a potential primary measurement technique for quantifying the main component within a chemical material, and its use is becoming more widespread amongst NMIs for primary calibrator value assignment. The current focus of the programme is to improve qNMR methodology so that international comparability at levels of parts in the 103 can be achieved for a broad range of compounds.

The establishment of a qNMR laboratory at the BIPM has been possible the donation of a 400 MHz NMR instrument from JEOL France* (*this acknowledgement does not constitute an endorsement of the instrument).

The qNMR programme is expected to contribute to international guidelines for the application of 'Methods for the SI Value Assignment of the Purity of Organic Compounds', currently being developed under an IUPAC project chaired by the BIPM with active participation from eleven NMIs (BAM, LGC, LNE, NIM, NIST, NMIA, NMIJ, NRC, PTB, VSL, UME) and two international organizations (IAEA and IRMM).

The next pure organic comparisons to be coordinated by the BIPM are C-peptide, CCQM-K115 (2014), and Folic acid, CCQM‑K55.d (2015).