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Reference measurement systems for novel biomarkers

Methods for characterizing primary calibrators for the measurement of hepcidin, a major iron metabolism regulator, have been published in Analytical and Bioanalytical Chemistry[1]. The paper describes the work carried out by Dr Pauline Bros (LNE) during her secondment to the BIPM.

Interest in the accurate measurement of hepcidin in biological fluids has been driven by its role as a major hormone in iron metabolism in the body, as well as interest in its measurements in cerebral spinal fluid and its potential use in the management of iron-related neurological disorders. The collaborative work carried out between the BIPM and the LNE (France) by Dr Bros contributed to her PhD thesis on the development of mass spectrometry-based reference methods for Alzheimer's disease biomarkers[2].

As a short, multi-crosslinked peptide, hepcidin has also provided a model system for the development of analytical methods to underpin future rounds of the CCQM-K115 comparisons of peptide calibrator reference materials. The first comparison of this series on C-peptide, a linear peptide and biomarker in diabetes diagnostics, has recently been completed and published.



  1. P. Bros, R.D. Josephs, N. Stoppacher, G. Cazals, S. Lehmann, C. Hirtz, R.I. Wielgosz, V. Delatour: Impurity Determination for Hepcidin by Liquid Chromatography - High Resolution and Ion Mobility Mass Spectrometry for the Value Assignment of Candidate Primary Calibrators, Anal. Bioanal. Chem. (2017). doi:10.1007/s00216-017-0202-4 [Epub ahead of print]

  2. P. Bros : Développement de méthodes de référence pour spectrométrie de masse pour le dosage de biomarqueurs de la maladie d'Alzheimer, PhD thesis, Université de Montpellier, May 2016. https://tel.archives-ouvertes.fr/tel-01468265/document
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